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Situs inversus is the mirror image of situs solitus, which is normal asymmetric distribution of the abdominothoracic visceral organs.

Patients with situs ambiguous are considered isomeric in that they have organs with 2-right-sides or 2-left-sides, most commonly observed in relation to the atria of the heart.

Individuals with situs inversus or situs solitus do not experience fatal dysfunction of their organ systems, as general anatomy and morphology of the abdominothoracic organ-vessel systems are conserved.

Unfortunately, due to abnormal arrangement of organs in situs ambiguous, orientation across the left-right axis of the body is disrupted early in fetal development, resulting in severely flawed cardiac development and function in 50-80% of cases.

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